Professor, Env. and Occ. Health Sciences
Dr. Rosenfeld studies nutrition and cardiovascular disease, role of nutrition in regulation of gene expression, lipid and lipoprotein metabolism, pathology of atherosclerosis. The research focuses on the pathogenesis of atherosclerosis with an emphasis on the role that macrophages play in this process. We are currently studying the heterogenous nature of macrophage subpopulations by demonstrating differences in the stages of differentiation and activation of the cells. We are also studying the effects of inflammatory mediators such as oxidized LDL on the expression of growth factors and cytokines by isolated macrophage-derived foam cells and are attempting to expression clone potential foam cell specific neoantigens.
PhD Nutritional Science, University of Wisconsin, 1981
MS Cell Biology, University of Vermont, 1978
BA Biology, Grinnell College, 1975