University of Washington School of Public Health
Associate Professor, Allergy and Infectious Dis.
325 Ninth Avenue
Dr. Chung's current research interests include cervical cancer, cost effectiveness, antiretroviral drug resistance, adherence, HIV pulmonary disease, Chinese migrant health, and HIV implementation science.
Dr. Chung is currently leading a trial randomizing HIV positive-women with pre-cancerous lesions to cryotherapy or loop electrosurgical excision procedure (LEEP) and following them for two years. The CDC-funded trial has screened over 6,000 HIV-positive women in Kenya and builds upon work comparing various cervical cancer screening methods and their utility in this population. His HIV cervical cancer research portfolio includes an examination of human papillomavirus (HPV) and HIV co-infection, cost effectiveness of screening and treatment procedures in Kenya, cervical HIV shedding after treatment, and the benefit of cervical testing with p16/Ki-67 and methylation markers.
In collaboration with Dr. Lisa Frenkel at the Seattle Children’s Research Institute, Dr. Chung is examining the impact of inexpensive antiretroviral resistance testing using oligonucleotide ligation assay (OLA) to detect transmitted drug resistance. Their clinical trial is randomizing patients initiating antiretroviral therapy to OLA testing vs. no testing to determine whether baseline resistance testing can guide drug selection and thereby improve HIV viral suppression. Nearly a thousand HIV-positive patients are being enrolled in Kenya and the inexpensive technology has been transferred to the country for possible application more widely. Further research involves determining the cost-effectiveness of the intervention and development of a point-of-care assay.
The Hope Center clinical database contains information on over 20,000 HIV-positive patients that has been collected for over a decade. The database is a rich trove for implementation science research studies. With students, Dr. Chung has investigated many implementation science questions including the effect of political instability on drug adherence, the impact of co-trimoxazole prophylaxis on clinic retention, and growth rate of children on antiretroviral medications. His current studies include the impact of partner disclosure and alcohol on immune reconstitution, the association between clinic distance and adherence, and the development of chronic obstructive pulmonary disease (COPD) among HIV-positive children infected vertically.
MD Medicine (MD), University of Chicago, 1998
MPH International Health, Harvard University, 1998
BA Biology, English, Oberlin College, 1990