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Dr. Astley's primary area of expertise is Fetal Alcohol Spectrum Disorders (FASD). She is the director of Washington State FAS Diagnostic & Prevention Network (FAS DPN). The FAS DPN is a network of four WA State community-based clinics linked by the core clinical/research/training clinic at the Center on Human Development and Disability at the University of Washington. The mission of the FAS DPN is primary and secondary prevention of FASD through screening, diagnosis, intervention, training, education and research. Dr. Astley has developed a comprehensive system for diagnosing FASD "The FASD 4-Digit Diagnostic Code", the 4-Digit Code Online Course, FAS Facial Photographic Analysis Software for diagnosis and screening of the FAS facial features, and the Foster Care FAS Screening Program in King County.